|
KMID : 0390320080180020484
|
|
Chungbuk Medical Journal
2008 Volume.18 No. 2 p.484 ~ p.500
|
|
|
Association Between Preprocedural Thrombolysis In Myocardial Infarction (TIMI) Flow Grade and Biochemical Marker in Patients With Acute Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention.
|
|
Bae Jang-Wahn
Lee Kyu-Ho
Lee Won-Yik
Hwang Kyung-Kuk
Oh Tae-Geun
Kim Dong-Woon
Cho Myeong-Chan
|
|
|
Abstract
|
|
|
Purpose: Incidence of acute myocardial infarction (AMI) is steeply increased because the prevalence of hypertension, diabetes mellitus and dyslipidemia in Korea is increasing. One of proven prognostic factors in AMI is preprocedural TIMI (Thrombolysis In Myocardial infarction) flow grade. This study tried to enlighten the association between preprocedural TIMI flow grade in AMI patients who were treated by primary PCI (Percutaneous Coronary Intervention) and serum biochemical markers.
Subjects and Methods: We had retrospectively reviewed medical records of 241 patients who had admitted the emergency triage in Chungbuk National University Hospital with acute chest pain and diagnosed STEMI (ST segment elevation myocardial infarction) and treated with primary PCI from Jan. 2004 to Aug. 2007 and had analyzed statistical association between pre/postprocedural biochemical markers, clinical characteristics and preprocedural TIMI flow grade.
Results: Among 241 analyzed patients, distribution of TIMI flow 0,1,2,3 is 147:49:24:21 (60.9:20.3:9.9:8.7%) each. Preprocedural TIMI 0,1 patients showed higher peak creatine phosphokinase (CK) (2974±2634 vs 1978±2024 mg/dL, p=0.018), worse Killip class (p=0.0001), lower prevalence of dyslipidemia (43.9% vs 64.4%, p=0.011), compared to TIMI 2,3 patients. Initial CK, hs-CRP, NT-proBNP, cTnI (cardiac troponin I) had no relation with preprocedural TIMI flow.
Conclusion: Although preprocedural TIMI flow grade had no association with initial biochemical markers, poor preprocedural TIMI flow grade had significant correlation with higher peak CK level after the primary PCI. It is necessary that enlightening of long term clinical relevance of pre and post procedural TIMI flow and biochemical markers in AMI.
|
|
|
KEYWORD
|
|
|
myocardial infarction, Thrombolysis In Myocardial Infarction grade, biochemical marker
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|
|